SEPN

Septerna, Inc.
—

Company Information

Company Name
Septerna, Inc.
CIK
CIK0001984086
Category
<br>Emerging growth company
Ticker: Exchange
SEPN: Nasdaq
Fiscal Year End
December 31
Owner Organization
03 Life Sciences
SIC
2834
SIC Description
Pharmaceutical Preparations
Ticker
SEPN

SEC filing data through

Insider Sentiment

Last purchase
2025-03-07
Last sale
2026-09-01
Shares purchased (TTM)
0
Shares sold (TTM)
1,802,315
Buy ratio (TTM)0.0%

Institutional Sentiment

As of
2026-06-30
Institutional shares owned
47,289,031
Shares outstanding
45,040,075
Ownership
104.99%
+4.69% Y/Y

Earnings Market Reaction

Filing date
2026-08-10
Price on filing date
—
1-month reaction
-5.41%
3-month reaction
…
Drift continued4/7 (57%)
Faded / reversed3/7 (43%)

Balance Sheet

Values in millions ($)
Line item2026-06-302026-03-312025-12-312025-09-302025-06-302025-03-312024-12-312024-09-30Subscriber-only columnSubscriber-only columnSubscriber-only columnSubscriber-only columnSubscriber-only columnTrend
Assets Current
Cash And Cash Equivalents At Carrying Value857212132018921023888
Marketable Securities Current28827627015413712611342
Accounts Receivable Net Current12111090000
Prepaid Expense And Other Assets Current12101097663
Accounts And Other Receivables Net Current------0-
Assets Current396368411492334342357133
Marketable Securities Noncurrent144175158875362707
Property Plant And Equipment Net44445555
Operating Lease Right Of Use Asset2021212223232424
Restricted Cash Noncurrent11111111
Other Assets Noncurrent11110003
Assets567570596607415434457174
Liabilities Current
Accounts Payable Current471047436
Accrued Liabilities Current1391287486
Contract With Customer Liability Current60606262--0-
Operating Lease Liability Current22222221
Liabilities Current7978877515111313
Contract With Customer Liability Noncurrent8092106121--0-
Operating Lease Liability Noncurrent2021212223232424
Other Liabilities Noncurrent10000000
Liabilities18019121421838343738
Temporary Equity Carrying Amount Attributable To Parent-------224
Stockholders Equity
Common Stock Value00000000
Additional Paid In Capital Common Stock57755554954554254053810
Accumulated Other Comprehensive Income Loss Net Of Tax-1-1100000
Retained Earnings Accumulated Deficit-189-176-167-157-165-140-118-98
Stockholders Equity387378382389378-400420-87
Liabilities And Stockholders Equity567570596607415434457174
Temporary Equity Shares Authorized--0---0-
Preferred Stock Par Or Stated Value Per Share0.000.000.000.000.000.000.00-
Preferred Stock Shares Authorized10101010101010-
Temporary Equity Shares Issued--0---0-
Temporary Equity Shares Outstanding--0---0-
Preferred Stock Shares Issued0000000-
Preferred Stock Shares Outstanding0000000-
Common Stock Par Or Stated Value Per Share0.000.000.000.000.000.000.00-
Common Stock Shares Authorized500500500500500500500-
Common Stock Shares Issued46454545454444-
Shares Outstanding46454545454444-

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Septerna, Inc. (SEPN) — SEC Financial Statements & Analysis

Septerna, Inc. (SEPN) is a pharmaceutical preparations company, incorporated in DE. Septerna, Inc. trades on Nasdaq as: SEPN. Septerna, Inc. (SEPN)'s most recent SEC filing is a Form 10-Q for the period ended 2026-06-30, filed with the SEC on 2026-08-10. Based on that filing, Septerna, Inc. carries a market cap of $1.51B, a P/E ratio of -62.24x, a P/B ratio of 3.90x, a P/S ratio of 15.25x, an enterprise value of $1.42B, and an EV/EBITDA multiple of -33.98x. On profitability, it posts an operating margin of -44.04%, a net margin of -24.51%, a Return on Equity (ROE) of -6.34%, a Return on Assets (ROA) of -4.94%, and a Return on Invested Capital (ROIC) of -16.69%. Per share, it reports EPS of $-0.54, diluted EPS of $-0.54, free cash flow per share of $2.33, and a dividend per share of $0.00. Over the trailing year, it posted revenue growth of 6898.02% year-over-year, net income growth of -79.48% year-over-year, and EPS growth of -79.88% year-over-year. On the balance sheet, it maintains a current ratio of 4.99x, a quick ratio of 4.85x, working capital of $316.84M, a debt-to-equity ratio of 0.47x, a debt ratio of 0.32, free cash flow of $105.10M (TTM), and net debt of $-84.66M. Figures sourced from SEC EDGAR.

Market Cap
$1.51B
P/E TTM
-62.24x
EPS TTM
$-0.54
P/B TTM
3.90x
ROE TTM
-6.34%
ROA TTM
-4.94%
Debt To Equity
0.47x
Free Cash Flow TTM
$105.10M
Net Revenue TTM Growth 1Y
6898.02%

Data as of 2026-06-30 · Source: SEC EDGAR

Frequently Asked Questions

What industry is Septerna, Inc. in?

Septerna, Inc. (SEPN) operates in the Pharmaceutical Preparations industry.

What exchange does SEPN trade on?

Septerna, Inc. (SEPN) trades on the Nasdaq.

Where is Septerna, Inc. incorporated?

Septerna, Inc. is incorporated in DE.

When was Septerna, Inc. (SEPN)'s most recent SEC filing?

Septerna, Inc. (SEPN)'s most recent SEC filing is a Form 10-Q for the period ended 2026-06-30, filed with the SEC on 2026-08-10.

What is SEPN's market cap?

Septerna, Inc. (SEPN) has a market capitalization of $1.51B as of 2026-06-30.

What is SEPN's EPS (earnings per share)?

Septerna, Inc. (SEPN)'s trailing twelve month EPS is $-0.54 as of 2026-06-30.

What is SEPN's ROE (return on equity)?

Septerna, Inc. (SEPN)'s trailing twelve month Return on Equity (ROE) is -6.34% as of 2026-06-30.

What is SEPN's ROA (return on assets)?

Septerna, Inc. (SEPN)'s trailing twelve month Return on Assets (ROA) is -4.94% as of 2026-06-30.

What is SEPN's ROIC (return on invested capital)?

Septerna, Inc. (SEPN)'s trailing twelve month Return on Invested Capital (ROIC) is -16.69% as of 2026-06-30.

What is SEPN's EV/EBITDA?

Septerna, Inc. (SEPN)'s trailing twelve month EV/EBITDA is -33.98x as of 2026-06-30.

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