UPB
Upstream Bio, Inc.Company Information
- Company Name
- Upstream Bio, Inc.
- CIK
- CIK0002022626
- Category
- <br>Emerging growth company
- Ticker: Exchange
- UPB: Nasdaq
- Fiscal Year End
- December 31
- Owner Organization
- 03 Life Sciences
- SIC
- 2834
- SIC Description
- Pharmaceutical Preparations
- Ticker
- UPB
SEC filing data through
Insider Sentiment
- Last purchase
- 2024-10-15
- Last sale
- 2026-09-16
- Shares purchased (TTM)
- 0
- Shares sold (TTM)
- 15,061
Institutional Sentiment
- As of
- 2026-06-30
- Institutional shares owned
- 50,343,060
- Shares outstanding
- 54,567,976
- Ownership
- 92.26%
Earnings Market Reaction
- Filing date
- 2026-08-11
- Price on filing date
- —
- 1-month reaction
- -15.23%
- 3-month reaction
- …
Balance Sheet
Values in millions ($)| Line item | 2026-06-30 | 2026-03-31 | 2025-12-31 | 2025-09-30 | 2025-06-30 | 2025-03-31 | 2024-12-31 | 2024-09-30 | Subscriber-only column | Subscriber-only column | Subscriber-only column | Subscriber-only column | Subscriber-only column | Trend |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Series A And B Redeemable Convertible Preferred Stock | - | - | - | - | - | - | - | 0 | ||||||
Assets Current | ||||||||||||||
| Cash And Cash Equivalents At Carrying Value | 79 | 97 | 102 | 72 | 45 | 71 | 326 | 33 | ||||||
| Short Term Investments | 182 | 198 | 240 | 300 | 348 | 360 | 145 | 188 | ||||||
| Accounts Receivable Net Current | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Prepaid Expense And Other Assets Current | 18 | 21 | 10 | 16 | 24 | 22 | 8 | 6 | ||||||
| Assets Current | 280 | 316 | 352 | 389 | 418 | 454 | 479 | 227 | ||||||
| Property Plant And Equipment Net | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Operating Lease Right Of Use Asset | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | ||||||
| Restricted Cash Noncurrent | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||
| Assets | 281 | 318 | 354 | 391 | 421 | 456 | 482 | 233 | ||||||
Liabilities Current | ||||||||||||||
| Accounts Payable Current | 2 | 2 | 3 | 4 | 3 | 5 | 4 | 5 | ||||||
| Accrued Liabilities And Other Liabilities | 7 | 11 | 10 | 7 | 8 | 4 | 6 | 5 | ||||||
| Operating Lease Liability Current | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Liabilities Current | 10 | 14 | 13 | 12 | 11 | 10 | 11 | 11 | ||||||
| Operating Lease Liability Noncurrent | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Liabilities | 10 | 14 | 14 | 13 | 12 | 11 | 12 | 12 | ||||||
Stockholders Equity | ||||||||||||||
| Temporary Equity Carrying Amount Attributable To Parent | - | - | - | - | - | - | 0 | 381 | ||||||
| Common Stock Value | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||||
| Additional Paid In Capital | 686 | 679 | 673 | 670 | 666 | 663 | 661 | 9 | ||||||
| Accumulated Other Comprehensive Income Loss Net Of Tax | -0 | 0 | 1 | 0 | 0 | 0 | -0 | 0 | ||||||
| Retained Earnings Accumulated Deficit | -415 | -375 | -334 | -292 | -258 | -218 | -191 | -170 | ||||||
| Stockholders Equity | 271 | 304 | 340 | 379 | 409 | 446 | 470 | -160 | ||||||
| Liabilities And Stockholders Equity | 281 | 318 | 354 | 391 | 421 | 456 | 482 | 233 | ||||||
| Temporary Equity Shares Authorized | - | - | - | - | - | - | - | 32 | ||||||
| Temporary Equity Shares Issued | - | - | - | - | - | - | - | 32 | ||||||
| Temporary Equity Shares Outstanding | - | - | - | - | - | - | - | 32 | ||||||
| Temporary Equity Liquidation Preference | - | - | - | - | - | - | - | 431 | ||||||
| Preferred Stock Par Or Stated Value Per Share | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | - | ||||||
| Preferred Stock Shares Authorized | 10 | 10 | 10 | 10 | 10 | 10 | 10 | - | ||||||
| Preferred Stock Shares Issued | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | ||||||
| Preferred Stock Shares Outstanding | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | ||||||
| Common Stock Par Or Stated Value Per Share | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| Common Stock Shares Authorized | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 41 | ||||||
| Common Stock Shares Issued | 55 | 54 | 54 | 54 | 54 | 54 | 54 | 3 | ||||||
| Shares Outstanding | 55 | 54 | 54 | 54 | 54 | 54 | 54 | 3 | ||||||
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Recent filings
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Unlock 17+ years of income statements, balance sheets, and cash flow statements
Start 7-day free trialUpstream Bio, Inc. (UPB) — SEC Financial Statements & Analysis
Upstream Bio, Inc. (UPB) is a pharmaceutical preparations company, incorporated in DE. Upstream Bio, Inc. trades on Nasdaq as: UPB. Upstream Bio, Inc. (UPB)'s most recent SEC filing is a Form 10-Q for the period ended 2026-06-30, filed with the SEC on 2026-08-11. Based on that filing, Upstream Bio, Inc. carries a market cap of $377.61M, a P/E ratio of -2.41x, a P/B ratio of 1.39x, a P/S ratio of 119.57x, an enterprise value of $298.21M, and an EV/EBITDA multiple of -1.76x. On profitability, it posts an operating margin of -5382.65%, a net margin of -4955.67%, a Return on Equity (ROE) of -46.05%, a Return on Assets (ROA) of -44.61%, and a Return on Invested Capital (ROIC) of -61.26%. Per share, it reports EPS of $-2.87, diluted EPS of $-2.87, free cash flow per share of $-2.50, and a dividend per share of $0.00. Over the trailing year, it posted revenue growth of -18.46% year-over-year, net income growth of 8.96% year-over-year, and EPS growth of 7.37% year-over-year. On the balance sheet, it maintains a current ratio of 27.99x, a quick ratio of 26.24x, working capital of $269.61M, a debt-to-equity ratio of 0.04x, a debt ratio of 0.04, free cash flow of $-136.46M (TTM), and net debt of $-79.40M. Figures sourced from SEC EDGAR.
- Market Cap
- $377.61M
- P/E TTM
- -2.41x
- EPS TTM
- $-2.87
- P/B TTM
- 1.39x
- ROE TTM
- -46.05%
- ROA TTM
- -44.61%
- Debt To Equity
- 0.04x
- Free Cash Flow TTM
- $-136.46M
- Net Revenue TTM Growth 1Y
- -18.46%
Data as of 2026-06-30 · Source: SEC EDGAR
Frequently Asked Questions
What industry is Upstream Bio, Inc. in?
Upstream Bio, Inc. (UPB) operates in the Pharmaceutical Preparations industry.
What exchange does UPB trade on?
Upstream Bio, Inc. (UPB) trades on the Nasdaq.
Where is Upstream Bio, Inc. incorporated?
Upstream Bio, Inc. is incorporated in DE.
When was Upstream Bio, Inc. (UPB)'s most recent SEC filing?
Upstream Bio, Inc. (UPB)'s most recent SEC filing is a Form 10-Q for the period ended 2026-06-30, filed with the SEC on 2026-08-11.
What is UPB's market cap?
Upstream Bio, Inc. (UPB) has a market capitalization of $377.61M as of 2026-06-30.
What is UPB's EPS (earnings per share)?
Upstream Bio, Inc. (UPB)'s trailing twelve month EPS is $-2.87 as of 2026-06-30.
What is UPB's ROE (return on equity)?
Upstream Bio, Inc. (UPB)'s trailing twelve month Return on Equity (ROE) is -46.05% as of 2026-06-30.
What is UPB's ROA (return on assets)?
Upstream Bio, Inc. (UPB)'s trailing twelve month Return on Assets (ROA) is -44.61% as of 2026-06-30.
What is UPB's ROIC (return on invested capital)?
Upstream Bio, Inc. (UPB)'s trailing twelve month Return on Invested Capital (ROIC) is -61.26% as of 2026-06-30.
What is UPB's EV/EBITDA?
Upstream Bio, Inc. (UPB)'s trailing twelve month EV/EBITDA is -1.76x as of 2026-06-30.